CSNK2A1

casein kinase 2, alpha 1 polypeptide

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

CSNK2A1 (12)

Publications

No (12)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His, N-Terminal (1)

His-GST (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (2)

Insect Cells (2)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human CSNK2A1 Protein (Recombinant His) - LS-G1673

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human CSNK2A1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45 kDa

Price:

20 µg/$1,107

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Human CSNK2A1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G58246

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CSNK2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75023

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45 kDa

Price:

20 µg/$150

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CSNK2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118326

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45 kDa

Price:

100 µg/$494

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Human CSNK2A1 Protein (Recombinant GST, N-terminus) (Met1-Gln391) - LS-G140005

Source:

Insect Cells

Tag:

GST, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.4 kDa

Price:

50 µg/$707

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Human CSNK2A1 Protein (Recombinant His-SUMO) (Full Length) - LS-G20638

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

61.11 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CSNK2A1 Protein (Recombinant GST) (Full Length) - LS-G28068

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CSNK2A1 Protein (Recombinant His) - LS-G3511

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Mouse CSNK2A1 Protein (Recombinant) (Met1-Gln391) - LS-G140018

Source:

Insect Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.3 kDa

Price:

50 µg/$625

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Mouse CSNK2A1 Protein (Recombinant His-GST) (Met1-Gln391) - LS-G98746

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.9 kDa

Price:

50 µg/$707

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Human CSNK2A1 Protein (Recombinant His, N-Terminal) - LS-G144004

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29 kDa

Price:

50 µg/$419

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