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CSF1 / MCSF

colony stimulating factor 1 (macrophage)

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Gene Name: colony stimulating factor 1 (macrophage)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: CSF1, CSF-1, MCSF, M-CSF, Lanimostim, CSFM
Target Sequences: NM_000757 NP_000748.3 P09603

Publications (1)

1
FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma. Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liangzhan Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yongxu Jia, Dora Lai-Wan Kwong, NgarWoon Kam, Xin-Yuan Guan. Theranostics. 2020 October;10:11535-11548. [Full Text Article] [PubMed:33052231] [PMC:PMC7546008] Related Antibodies: LS-C104656.

☰ Filters
Products
Proteins (53)
Over-Expression Lysate (10)
Recombinant (42)
CSF1 / MCSF (53)
Animal-free (3)
No (53)
6His, C-terminus (5)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His, C-Terminal (1)
His, N-Terminal (1)
His-GST-S (1)
His-T7 (1)
Myc-DDK (Flag) (14)
Human (28)
Mouse (14)
Rat (5)
293T Cells (5)
CHO Cells (3)
E. coli (17)
HEK 293 Cells (13)
Human (1)
Human Cells (4)
Mammalian Cells (5)
Wheat Germ Extract (2)
Purified (20)
Low endotoxin level (28)
Biologically active (24)
Animal-free (3)
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
32-40 kDa (SDS-PAGE)
5 µg/$278; 25 µg/$364
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
35-44 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
CSF1 / MCSF Protein - M-NFS-60 cell proliferation induced by human M-CSF.
Select
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 179 amino acid recombinant protein has a predicted molecular mass of approximately 20.6 kD. The DTT-reduced and non-reduced protein migrate at approximately 25- 35 kD and 55-70 kD respectively by SDS-PAGE. The N-terminal contains a His9-(SGGG)2-IEGR-t
10 µg/$283; 25 µg/$344; 100 µg/$689; 500 µg/$1,595
CSF1 / MCSF Protein - Biological Activity M-CSF, Human stimulates cell proliferation of M-NFS-60 cells. The ED 50 for this effect is less than 5ng/mL.
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
32-40 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
CSF1 / MCSF Protein - Purified recombinant protein CSF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,107
CSF1 / MCSF Protein - Purified recombinant protein CSF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
29 kDa
20 µg/$1,107
CSF1 / MCSF Protein - Purified recombinant protein CSF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$1,107
CSF1 / MCSF Protein - Purified recombinant protein CSF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$1,107
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
29 kDa
100 µg/$494
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$494
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.7 kDa
100 µg/$710
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$150
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$215
Select
293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$150
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
29 kDa
20 µg/$150
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$150
CSF1 / MCSF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
26.17 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,404; 500 µg/$2,385
Select
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
20 µg/$428
CSF1 / MCSF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
26 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$2,167
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$494
CSF1 / MCSF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$494
CSF1 / MCSF Protein - M-NFS-60 cell proliferation induced by mouse M-CSF.
Select
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 251 amino acid recombinant protein has a predicted molecular mass of approximately 28.2 kD. The DTT-reduced and non-reduced protein migrate at approximately 50 kD and 100 kD respectively by SDS-PAGE. The N-terminal contains a His9-(SGGG)2-IEGR-tag.
10 µg/$276; 25 µg/$310; 100 µg/$535; 500 µg/$1,828
CSF1 / MCSF Protein - The ED50 as determined by the dose-dependent stimulation of the proliferation of M-NFS-60 cells was found to be < 1.0 ng/mL
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18.5 kDa
10 µg/$432; 1 mg/$8,695
CSF1 / MCSF Protein - Recombinant Mouse M-CSF/CSF1 Protein-Elabscience
Select
Human
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
26.0 kDa
10 µg/$317; 50 µg/$524
Viewing 1-25 of 53 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).