order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
CS1 / CLSTN1
calsyntenin 1
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
| Gene Name: | calsyntenin 1 |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | CLSTN1, Alcadein-alpha, Alcadein alpha 1, Alcalpha2, Alcalpha1, CS1, CSTN1, CDHR12, ALC-ALPHA, XB31alpha, Calsyntenin 1, Calsyntenin-1, KIAA0911 |
| Target Sequences: | NM_014944 NP_055759.3 O94985 |
Publications (1)
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
