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Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.
Gene Name: | calsyntenin 1 |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | CLSTN1, Alcadein-alpha, Alcadein alpha 1, Alcalpha2, Alcalpha1, CS1, CSTN1, CDHR12, ALC-ALPHA, XB31alpha, Calsyntenin 1, Calsyntenin-1, KIAA0911 |
Target Sequences: | NM_014944 NP_055759.3 O94985 |
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