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Vector Laboratories, Inc.
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CS1 / CLSTN1

calsyntenin 1

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.

Gene Name: calsyntenin 1
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: CLSTN1, Alcadein-alpha, Alcadein alpha 1, Alcalpha2, Alcalpha1, CS1, CSTN1, CDHR12, ALC-ALPHA, XB31alpha, Calsyntenin 1, Calsyntenin-1, KIAA0911
Target Sequences: NM_014944 NP_055759.3 O94985

Publications (1)

1
Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity. Morales DM, Townsend RR, Malone JP, Ewersmann CA, Macy EM, Inder TE, Limbrick DD Jr. Molecular & cellular proteomics : MCP. 2012 11:M111. (WB; Human) [Full Text Article] [PubMed:22186713]

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Antibodies (25)
Proteins (6)
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CS1 / CLSTN1 (33)
Human (27)
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rabbit (25)
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CS1 / CLSTN1 Antibody - Anti-CS1 / CLSTN1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CS1 / CLSTN1 Antibody - Anti-CS1 / CLSTN1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa35-84) (HRP) Antibody
Zebrafish, Rat, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
CS1 / CLSTN1 Antibody - Anti-CS1 / CLSTN1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa35-84) (Biotin) Antibody
Zebrafish, Rat, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CS1 / CLSTN1 Antibody - Anti-CS1 / CLSTN1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody
Zebrafish, Rat, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
CS1 / CLSTN1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
CS1 / CLSTN1 Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
Select
CS1 / CLSTN1 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
CS1 / CLSTN1 Antibody - CLSTN1 Antibody western blot of 293 cell line lysates (35 ug/lane). The CLSTN1 antibody detected the CLSTN1 protein (arrow).
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (aa15-42) Antibody
Human
WB
Unconjugated
400 µl/$393
CS1 / CLSTN1 Antibody - Western blot analysis of extracts of various cell lines, using CLSTN1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CS1 / CLSTN1 Antibody - Immunochemical staining of human CLSTN1 in human brain with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.
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CS1 / CLSTN1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
IHC-P
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-25 of 33 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).