CRYBA1

crystallin, beta A1

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CRYBA1 (5)

Publications

No (5)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CRYBA1 Protein (Recombinant GST) (Full Length) - LS-G28041

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse CRYBA1 Protein (Recombinant His-T7) (aa1-215) - LS-G25588

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.9 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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CRYBA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116108

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

100 µg/$494

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Human CRYBA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65051

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

20 µg/$1,107

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Human CRYBA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74734

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

20 µg/$150

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