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CRTC1 / MECT1 / TORC1
CREB regulated transcription coactivator 1
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
| Gene Name: | CREB regulated transcription coactivator 1 |
| Synonyms: | CRTC1, KIAA0616, MECT1, TORC-1, TORC1, Transducer of CREB protein 1, WAMTP1 |
| Target Sequences: | NM_001098482 NP_001091952.1 Q6UUV9 |
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