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CRLF2 / TSLPR

cytokine receptor-like factor 2

CRLF2 / TSLPR is a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

Gene Name: cytokine receptor-like factor 2
Synonyms: CRLF2, IL-XR, ILXR, p2RY8/CRLF2 fusion, TSLP receptor, TSLPR, CRL2, CRLF2Y, Cytokine receptor-like 2
Target Sequences: AK026800 BAB15557.1 Q9HC73

Publications (1)

1
Anti-CRLF2 Antibody-Armored Biodegradable Nanoparticles for Childhood B-ALL. Raghunathan R, Mahesula S, Kancharla K, Janardhanan P, Jadhav YL, Nadeau R, Villa GP, Cook RL, Witt CM, Gelfond JA, Forsthuber TG, Haskins WE. Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems. 2013 30:355-364. (WB; Human) [Full Text Article] [PubMed:23976822] [PMC:PMC3746557] Related Antibodies: LS-C40791.

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Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
CRLF2 / TSLPR (10)
No (10)
6His, C-terminus (2)
Fc, C-terminus (3)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (6)
Mouse (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Human (2)
Human Cells (1)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (5)
CRLF2 / TSLPR Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CRLF2 / TSLPR Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CRLF2 / TSLPR Protein - Purified recombinant protein CRLF2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.8 kDa
20 µg/$1,107
CRLF2 / TSLPR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.8 kDa
20 µg/$150
CRLF2 / TSLPR Protein - Recombinant Human Thymic Stromal Lymphopoietin Receptor/TSP R/CRLF2 (C-6His)
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Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.8 kDa
10 µg/$290; 50 µg/$446
CRLF2 / TSLPR Protein - Recombinant Human TSLP R/CRLF2 (C-Fc)
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Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.9 kDa
10 µg/$290; 50 µg/$446
CRLF2 / TSLPR Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.8 kDa
100 µg/$494
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Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.8 kDa
10 µg/$317; 50 µg/$524
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.7 kDa
10 µg/$317; 50 µg/$524
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).