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CRKL
v-crk avian sarcoma virus CT10 oncogene homolog-like
CRKL is a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
| Gene Name: | v-crk avian sarcoma virus CT10 oncogene homolog-like |
| Synonyms: | CRKL, Crk-like protein |
| Target Sequences: | NM_005207 NP_005198.1 P46109 |
Publications (1)
1
A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development. Miller KA, Tan TY, Welfare MF, White SM, Stark Z, Savarirayan R, Burgess T, Heggie AA, Caruana G, Bertram JF, Bateman JF, Farlie PG. Molecular syndromology. 2014 5:276-86. (WB; Human)
[PubMed:25565927]
Related Antibodies: LS-C14694.
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Products
ELISA Kits
(5)
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Cell-Based
(1)
Cell-Based Phosphorylation
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(3)
Target
CRKL
(5)
Reactivity
Human
(4)
Mouse
(3)
Rat
(2)
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96-Well Microplate
(3)
96-Well Strip Plate
(2)
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(5)
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Adherent Cell Cultures
(2)
Cell Culture Supernatants
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Cell Lysates
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Sandwich
96-Well Microplate
Human
0.205 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
2 Plates/$668
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
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