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CRH / CRF

corticotropin releasing hormone

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Gene Name: corticotropin releasing hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: CRH, CRF, Corticoliberin
Target Sequences: NM_000756 NP_000747.1 P06850

Publications (2)

1
Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression. Cristina A Martinez, Ina Marteinsdottir, Ann Josefsson, Gunilla Sydsjö, Elvar Theodorsson, Heriberto Rodriguez-Martinez. Genes. 2020 July;11: [Full Text Article] [PubMed:32752005] [PMC:PMC7463995] Related Antibodies: LS-B11889.
2
Circulating levels of urocortin neuropeptides are impaired in children with overweight. Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Sriraman Devarajan, Samia Warsame, Hessa AlKandari, Maria AlMahdi, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss. Obesity (Silver Spring, Md.). 2022 Feburary;30:472-481. [Full Text Article] [PubMed:35088550] [PMC:PMC9305428]

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Antibodies (107)
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CRH / CRF (107)
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CRH / CRF Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CRH / CRF Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CRH / CRF Antibody - Anti-CRH antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250 µl/$505
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CRH / CRF Mouse anti-Human Monoclonal Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
Unconjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$577; 2 ml/$789; 5 ml/$1,281
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CRH / CRF Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
HRP Conjugated
100 µl/$344; 200 µl/$401; 500 µl/$591; 1 ml/$734; 2 ml/$971; 5 ml/$1,667
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CRH / CRF Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
Biotin Conjugated
100 µl/$323; 200 µl/$372; 500 µl/$533; 1 ml/$620; 2 ml/$853; 5 ml/$1,411
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CRH / CRF Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
PE Conjugated
100 µl/$415; 200 µl/$503; 500 µl/$879; 1 ml/$1,042; 2 ml/$1,367; 5 ml/$2,563
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CRH / CRF Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
APC Conjugated
100 µl/$415; 200 µl/$503; 500 µl/$879; 1 ml/$1,042; 2 ml/$1,367; 5 ml/$2,563
CRH / CRF Antibody - Western Blot analysis of CRH expression in transfected 293T cell line by CRH monoclonal antibody (M02), clone 2B11.Lane 1: CRH transfected lysate(21.4 KDa).Lane 2: Non-transfected lysate.
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CRH / CRF Mouse anti-Human Monoclonal (2B11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Cat, Human
ELISA
Unconjugated
400 µg/$878
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Human
IP, RIA
Unconjugated
100 µl/$600
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CRH / CRF Mouse anti-Human Monoclonal (5D5) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.2 mg/$486
CRH / CRF Antibody - Immunohistochemistry of CRH in human brain tissue with CRH antibody at 5 ug/mL.
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
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CRH / CRF Rabbit anti-Sheep Polyclonal Antibody
Sheep
ICC, IHC
Unconjugated
50 µl/$572
CRH / CRF Antibody - E coli-derived fusion protein as test antigen. CRH / CRF Antibody dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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CRH / CRF Chicken anti-Human Polyclonal (aa27-196) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$818
CRH / CRF Antibody - Western blot of recombinant CRH / CRF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Mouse Polyclonal (aa28-160) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CRH / CRF Antibody - Western blot of recombinant CRH / CRF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Rat Polyclonal (aa39-187) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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CRH / CRF Mouse anti-Human Monoclonal (4H9) Antibody
Human
ELISA, IF, IHC-Fr, IHC-P
Unconjugated
0.2 mg/$486
CRH / CRF Antibody - 1:100 staining human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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CRH / CRF Mouse anti-Human Monoclonal Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$305; 200 µl/$346; 500 µl/$481; 1 ml/$549; 2 ml/$729; 5 ml/$1,197
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CRH / CRF Mouse anti-Human Monoclonal (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
100 µl/$334; 200 µl/$386; 500 µl/$562; 1 ml/$677; 2 ml/$914; 5 ml/$1,539
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CRH / CRF Mouse anti-Human Monoclonal (PE) Antibody
Human
ICC, IP, WB
PE Conjugated
100 µl/$400; 200 µl/$481; 500 µl/$826; 1 ml/$982; 2 ml/$1,263; 5 ml/$2,367
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CRH / CRF Mouse anti-Human Monoclonal (APC) Antibody
Human
ICC, IP, WB
APC Conjugated
100 µl/$400; 200 µl/$481; 500 µl/$826; 1 ml/$982; 2 ml/$1,263; 5 ml/$2,367
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CRH / CRF Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).