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CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]
Gene Name: | C3 And PZP-like, Alpha-2-macroglobulin Domain Containing 8 |
Synonyms: | CPAMD8, KIAA1283, K-CAP |
Target Sequences: | AB033109 BAA86597.1 Q8IZJ3 |
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