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CPA1 / Carboxypeptidase A is a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer.
Gene Name: | carboxypeptidase A1 (pancreatic) |
Family/Subfamily: | Exopeptidase , Metallopeptidase M14 |
Synonyms: | CPA1, CPA, Carboxypeptidase A1, Pancreatic carboxypeptidase A, Carboxypeptidase A |
Target Sequences: | NM_001868 NP_001859.1 P15085 |
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