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Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
Gene Name: | cytochrome c oxidase subunit IV isoform 2 (lung) |
Synonyms: | COX4I2, COX4-2, COX4B, COX4, COX4L2, COX IV-2, COXIV-2, DJ857M17.2 |
Target Sequences: | NM_032609 NP_115998.2 Q96KJ9 |
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