COX10

cytochrome c oxidase assembly homolog 10 (yeast)

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

COX10 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human COX10 Protein (Recombinant GST, N-terminus) (aa26-100) - LS-G58188

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human COX10 Protein (Recombinant GST) (Full Length) - LS-G27995

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74.36 kDa

Price:

10 µg/$479; 25 µg/$670

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Human COX10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81433

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.7 kDa

Price:

20 µg/$150

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COX10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118673

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.7 kDa

Price:

100 µg/$494

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