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CORO2A encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants.
Gene Name: | coronin, actin binding protein, 2A |
Synonyms: | CORO2A, Coronin-2A, Coronin-like protein B, CLIPINB, Coronin 2A, IR10, WD repeat-containing protein 2, WD protein IR10, WD-repeat protein 2, WDR2 |
Target Sequences: | NM_003389 |
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