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Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.Isoform 2: has weaker endopeptidase activity compared to isoform 1.
Gene Name: | corin, serine peptidase |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | CORIN, ATC2, Corin, serine protease, Corin, serine peptidase, PEE5, Pro-ANP-convertase, Pro-ANP-converting enzyme, TMPRSS10, PRSC, CRN |
Target Sequences: | NM_006587 NP_006578.2 Q9Y5Q5 |
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