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Newark, CA 94560
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COQ3
coenzyme Q3 methyltransferase
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]
| Gene Name: | coenzyme Q3 methyltransferase |
| Synonyms: | COQ3, DHHB methyltransferase, DHHB-MTase, DHHBMT, DHHB-MT, Methyltransferase COQ3, BA9819.1, DHHBMTASE, UG0215E05 |
| Target Sequences: | NM_017421 NP_059117.3 Q9NZJ6 |
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