COPS7A

COP9 signalosome subunit 7A

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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Proteins (4)

Type

Recombinant (4)

Target

COPS7A (4)

Publications

No (4)

Tag

GST (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (1)

Species

Human (4)

Source

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human COPS7A Protein (Recombinant His) - LS-G2865

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human COPS7A Protein (Recombinant GST) (Full Length) - LS-G33552

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.7 kDa

Price:

2 µg/$439

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Human COPS7A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69976

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.1 kDa

Price:

20 µg/$1,107

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Human COPS7A Protein (Recombinant His-SUMO) (Full Length) - LS-G21971

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

46.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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