Complement C2

complement component 2

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

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Products

Proteins (13)

Type

Over-Expression Lysate (4)

Recombinant (9)

Target

Complement C2 (13)

Application

SDS-PAGE (3)

Publications

No (13)

Tag

6His, N-terminus (1)

Fc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His,C-terminus (2)

His-T7 (1)

Human IgG Fc, C-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (9)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (6)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (5)

Biologically Active

Biologically active (1)

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Rat Complement C2 Protein (Recombinant 6His, N-terminus) (aa473-723) - LS-G24148

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

31.6 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Mouse Complement C2 Protein (Recombinant His,C-terminus) (Met1-Leu760) - LS-G49171

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse C2 comprises 752 amino acids and has a predicted molecular mass of 84.2 kDa. The apparent molecular mass of the protein is approximately 91.2 kDa in SDS-PAGE under reducing conditions.

Price:

20 µg/$317

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Human Complement C2 Protein (Recombinant GST) (Full Length) - LS-G27679

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

109.7 kDa

Price:

2 µg/$439

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Human Complement C2 Protein (Recombinant GST, N-terminus) (aa21-243) - LS-G57934

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human Complement C2 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Leu752) - LS-G47379

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human complement component C2/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 970 amino acids and has a calculated molecular mass of 110 kDa. As a result of glycosylation, the apparent molecular mass of rhC2/Fc monomer is approximately 110-130 kDa in reduced SDS-PAGE.

Price:

20 µg/$317

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Human Complement C2 Protein (Recombinant His,C-terminus) (Met1-Leu752) - LS-G47439

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The single-chain form of recombinant human complement component C2 comprises 743 amino acids and has a calculated molecular mass of 82.5 kDa.

Price:

20 µg/$317

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Human Complement C2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75278

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.27 kDa

Price:

20 µg/$150

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Human Complement C2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75279

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.44 kDa

Price:

20 µg/$150

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Complement C2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126861

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.44 kDa

Price:

100 µg/$494

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Human Complement C2 Protein (Recombinant His-T7) (aa245-451) - LS-G13004

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.3 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human Complement C2 Protein (Recombinant His) (Met1-Leu752) - LS-G98875

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.5 kDa

Price:

20 µg/$515

Select

Complement C2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98911

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.27 kDa

Price:

100 µg/$494

Select

Human Complement C2 Protein (Recombinant Fc, C-terminus) (Met1-Leu752) - LS-G138443

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

110 kDa

Price:

20 µg/$603

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