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Vector Laboratories, Inc.
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COMP / THBS5

cartilage oligomeric matrix protein

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Gene Name: cartilage oligomeric matrix protein
Synonyms: COMP, MED, PSACH, Thrombospondin-5, TSP5, THBS5, EDM1, EPD1
Target Sequences: NM_000095 NP_000086.2 P49747

Publications (1)

1
Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer. Junki Harada, Yasuyoshi Miyata, Kyohei Araki, Tsuyoshi Matsuda, Yoshiaki Nagashima, Yuta Mukae, Kensuke Mistunari, Tomohiro Matsuo, Kojiro Ohba, Yasushi Mochizuki, Hideki Sakai. In Vivo. 2021 April;35:1693-1701. [Full Text Article] [PubMed:33910854] [PMC:PMC8193323]

☰ Filters
Products
Antibodies (88)
Primary (88)
COMP / THBS5 (88)
Human (44)
Mouse (45)
Rat (39)
Dog (3)
Horse (3)
Pig (11)
IHC (12)
IHC-Fr (2)
IHC-P (5)
WB (80)
Flo (1)
ELISA (22)
IF (2)
IP (2)
Peptide-ELISA (2)
rabbit (80)
mouse (5)
chicken (2)
rat (1)
Product Group
IHCPlus (1)
IgG (20)
IgG1 (5)
IgG2a (1)
IgY (2)
monoclonal mc (6)
polyclonal pc (82)
4H6G10D2 (1)
MA37C94 (HC484D1) (1)
APC (6)
APC Conjugated (7)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (6)
Cy7 Conjugated (6)
FITC Conjugated (9)
HRP Conjugated (8)
PE Conjugated (7)
Preservative Free (2)
Unconjugated (36)
aa317-455 (10)
aa554-753 (9)
aa123-240 (8)
aa235-423 (8)
aa35-179 (8)
aa40-180 (8)
aa314-343 (7)
N-Terminus (4)
aa20-160 (2)
C-Terminus (1)
No (88)
COMP / THBS5 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
COMP / THBS5 Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with COMP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa314-343) Antibody
Human
Flo, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
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COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Western blot. All lanes: Cartilage oligomeric matrix protein antibody at 4 ug/ml+mouse skeletal muscle tissue. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 83 kDa. Observed band size: 83 kDa.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa20-160) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa20-160) Antibody
Human
ELISA
Unconjugated
50 µl/$294; 100 µl/$360
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Rat, Pig, Horse, Human
WB
HRP Conjugated
100 µl/$469
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Rat, Pig, Horse, Human
WB
Biotin Conjugated
100 µl/$469
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COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using COMP Polyclonal Antibody at dilution of 1:50.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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COMP / THBS5 Rat anti-Human Monoclonal (MA37C94 (HC484D1)) Antibody
Human
ELISA, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2 mg/$486
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COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using COMP Polyclonal Antibody at dilution of 1:50.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) Antibody
Pig, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) (HRP) Antibody
Pig, Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
COMP / THBS5 Antibody - IHC analysis of COMP using anti-COMP antibody. COMP was detected in paraffin-embedded section of human placenta tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-COMP Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
COMP / THBS5 Antibody - IHC staining of FFPE human ovarian cancer with COMP antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
100 µg/$575
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
Select
COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
COMP / THBS5 Antibody - Immunofluorescence analysis of U2OS cells using COMP Polyclonal Antibody.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
COMP / THBS5 Antibody - Immunohistochemistry of paraffin-embedded rat trachea using COMP antibody at dilution of 1:100 (40x lens).
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa314-343) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa314-343) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
IP, WB
Unconjugated
100 µg/$884
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).