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Collagen I

Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is encoded by the COL1A1 gene. Collagen alpha-2(I) chain is encoded by the COL1A2 gene. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes.

Collagen I Target Details

Target Name:

Collagen I

Publications (18)

Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Stefanovic B, Schnabl B, Brenner DA. The Journal of biological chemistry. 2002 277:18229-37. [PubMed:11889120]

Bone marrow-derived progenitor cells in pulmonary fibrosis. Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH. The Journal of clinical investigation. 2004 113:243-52. [PubMed:14722616] [PMC:PMC310750]

Adipogenic transcriptional regulation of hepatic stellate cells. She H, Xiong S, Hazra S, Tsukamoto H. The Journal of biological chemistry. 2005 280:4959-67. [PubMed:15537655]

Hepatic steatosis, fibrosis, and cancer in elderly cadavers. Mak KM, Kwong AJ, Chu E, Hoo NM. Anatomical record (Hoboken, N.J. : 2007). 2012 295:40-50. [PubMed:22139908]

The C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthma. Isgrò M, Bianchetti L, Marini MA, Bellini A, Schmidt M, Mattoli S. Mucosal immunology. 2013 6:718-27. (Flo; Human) [Full Text Article] [PubMed:23149666] Related Antibodies: LS-C79516.

Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma. Chakir J, Haj-Salem I, Gras D, Joubert P, Beaudoin ÈL, Biardel S, Lampron N, Martel S, Chanez P, Boulet LP, Laviolette M. Annals of the American Thoracic Society. 2015 November;12:1612-8. (Human) [Full Text Article] [PubMed:26325484]

Subtype-Specific Tumor-Associated Fibroblasts Contribute to the Pathogenesis of Uterine Leiomyoma. Wu X, Serna VA, Thomas J, Qiang W, Blumenfeld ML, Kurita T. Cancer research. 2017 December;77:6891-6901. [Full Text Article] [PubMed:29055020] [PMC:PMC6015476]

Substance P increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent and independent pathways in tenocytes. Frara N, Fisher PW, Zhao Y, Tarr JT, Amin M, Popoff SN, Barbe MF. Connective tissue research. 2018 January;59:30-44. [Full Text Article] [PubMed:28399671] [PMC:PMC5581284]

Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task. Barbe MF, White AR, Hilliard BA, Salvadeo DM, Amin M, Harris MY, Cruz GE, Hobson L, Popoff SN. Journal of Musculoskeletal and Neuronal Interactions. 2019 December;19:396-411. [Full Text Article] [PubMed:31789291] [PMC:PMC6944794]

Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]

Key indicators of repetitive overuse-induced neuromuscular inflammation and fibrosis are prevented by manual therapy in a rat model. Mary F Barbe, Michele Y Harris, Geneva E Cruz, Mamta Amin, Nathan M Billett, Jocelynne T Dorotan, Emily P Day, Seung Y Kim, Geoffrey M Bove. BMC musculoskeletal disorders. 2021 May;22:417. [Full Text Article] [PubMed:33952219] [PMC:PMC8101118]

Mesenchymal stromal cells from human umbilical cords display poor chondrogenic potential in scaffold-free three dimensional cultures. A Islam, A K Hansen, C Mennan, I Martinez-Zubiaurre. European cells & materials. 2016 May;31:407-24. [Full Text Article] [PubMed:27232667] Related Antibodies: LS-B3653.

DPP4 Inhibition, NPY1-36, PYY1-36, SDF-1a, and a Hypertensive Genetic Background Conspire to Augment Cell Proliferation and Collagen Production: Effects That Are Abolished by Low Concentrations of 2-Methoxyestradiol. Edwin K Jackson, Delbert G Gillespie, Stevan P Tofovic. The Journal of pharmacology and experimental therapeutics. 2020 Apr;373:135-148. [Full Text Article] [PubMed:32015161] [PMC:PMC7174788]

Blocking substance P signaling reduces musculotendinous and dermal fibrosis and sensorimotor declines in a rat model of overuse injury. M F Barbe, B A Hilliard, P W Fisher, A R White, S P Delany, V J Iannarone, M Y Harris, M Amin, G E Cruz, S N Popoff. Connective tissue research. 2019 Nov;61:604-619. [Full Text Article] [PubMed:31443618] [PMC:PMC7036028]

Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury. Mary F Barbe, Siva Tejaa Panibatla, Michele Y Harris, Mamta Amin, Jocelynne T Dorotan, Geneva E Cruz, Geoffrey M Bove. Frontiers in physiology. 2021 Nov;12:755923. [Full Text Article] [PubMed:34803739] [PMC:PMC8600143]

Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013]

Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles. Brendan A Hilliard, Mamta Amin, Steven N Popoff, Mary F Barbe. Connective tissue research. 2021 January;62:133-149. [Full Text Article] [PubMed:33030055] [PMC:PMC7718395]

Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats. Edwin K Jackson, Zaichuan Mi, Delbert G Gillespie, Dongmei Cheng, Stevan P Tofovic. Journal of the American Heart Association. 2021 March;10:e020088. [Full Text Article] [PubMed:33682436] [PMC:PMC8174220]

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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