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Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
Gene Name: | collectin sub-family member 12 |
Synonyms: | COLEC12, Collectin placenta protein 1, CL-P1, Collectin-12, HCL-P1, NSR2, SCARA4, SRCL, Collectin sub-family member 12 |
Target Sequences: | NM_030781 |
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