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Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Gene Name: | collagen, type IV, alpha 2 |
Family/Subfamily: | Collagen , not assigned-Collagen |
Synonyms: | COL4A2, Canstatin, Collagen alpha-2(IV) chain, Collagen, type IV, alpha 2, ICH, POREN2 |
Target Sequences: | X05610 CAA29098.1 P08572 |
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