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COL15A1 / Collagen XV Alpha 1 is the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
Gene Name: | collagen, type XV, alpha 1 |
Family/Subfamily: | Collagen , not assigned-Collagen |
Synonyms: | COL15A1, Collagen alpha-1(XV) chain, Collagen, type XV, alpha 1, Collagen alpha 1(xv), Collagen type XV proteoglycan |
Target Sequences: | NM_001855 NP_001846.3 P39059 |
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