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CNTNAP2 / CASPR2

contactin associated protein-like 2

CNTNAP2 / CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

Gene Name: contactin associated protein-like 2
Family/Subfamily: Neurexin , Not assigned-Other
Synonyms: CNTNAP2, AUTS15, CDFE, CASPR2, KIAA0868, PTHSL1, NRXN4
Target Sequences: NM_014141 NP_054860.1 Q9UHC6

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Products
Proteins (8)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (4)
CNTNAP2 / CASPR2 (8)
SDS-PAGE (1)
No (8)
His, N-Terminal (3)
His,C-terminus (2)
Myc-DDK (Flag) (3)
Human (5)
Mouse (2)
293T Cells (1)
HEK 293 Cells (7)
Low endotoxin level (2)
Biologically active (1)
CNTNAP2 / CASPR2 Protein
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HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse CASPR2 comprises 1246 amino acids and has a calculated molecular mass of 139 kDa. The recombinant protein migrates as an approximately 140-150 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$480
CNTNAP2 / CASPR2 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
~150 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
CNTNAP2 / CASPR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
148 kDa
20 µg/$150
CNTNAP2 / CASPR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
148 kDa
100 µg/$494
CNTNAP2 / CASPR2 Protein - Purified recombinant protein CNTNAP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
148 kDa
20 µg/$1,107
Select
HEK 293 Cells
His, N-Terminal
~138 kDa
200 µl/$283
Select
HEK 293 Cells
His, N-Terminal
~138 kDa
100 µg/$297
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
139 kDa
100 µg/$843
Viewing 1-8 of 8 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).