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Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
Gene Name: | contactin 6 |
Synonyms: | CNTN6, Contactin 6, NB3, HNB-3, Neural adhesion molecule, Contactin-6, NB-3 |
Target Sequences: | NM_014461 NP_055276.1 Q9UQ52 |
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