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CNTF

ciliary neurotrophic factor

CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

Gene Name: ciliary neurotrophic factor
Synonyms: CNTF, Ciliary neurotrophic factor, HCNTF
Target Sequences: NM_000614 NP_000605.1 P26441

Publications (1)

1
Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation. Kole C, Klipfel L, Yang Y, Ferracane V, Blond F, Reichman S, Millet-Puel G, Clérin E, Aït-Ali N, Pagan D, Camara H, Delyfer MN, Nandrot EF, Sahel JA, Goureau O, Léveillard T. Molecular therapy : the journal of the American Society of Gene Therapy. 2018 January;26:219-237. [Full Text Article] [PubMed:28988713] [PMC:PMC5762984]

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Products
Proteins (21)
Over-Expression Lysate (2)
Recombinant (19)
CNTF (21)
Animal-free (2)
No (21)
GST (1)
His (2)
His-S (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (12)
Mouse (1)
Pig (1)
Rabbit (1)
Rat (4)
293T Cells (1)
E. coli (16)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (9)
Low endotoxin level (10)
Biologically active (10)
Animal-free (2)
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
22.8 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$281; 20 µg/$369
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
22.7 kDa
5 µg/$268; 25 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 25 µg/$370
CNTF Protein
Select
E. coli
None
Biologically active
22.9 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
CNTF Protein - Recombinant Ciliary Neurotrophic Factor By SDS-PAGE
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E. coli
His
24.0 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
Select
E. coli
His
26.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
22.93kD
10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157
CNTF Protein - Purified recombinant protein CNTF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
22.8 kDa
20 µg/$1,107
CNTF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
22.8 kDa
20 µg/$150
Select
None
Biologically active
22.7 kD
20 µg/$481
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
22.93 kDa
10 µg/$297; 50 µg/$460
CNTF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
22.8 kDa
100 µg/$494
CNTF Protein - The ED50 as determined by the dose-dependent proliferation of human erythroleukemic cell line was found to be <2 ng/mL
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~22 kDa
20 µg/$357; 100 µg/$651; 1 mg/$4,099
CNTF Protein - The ED(50) was determined by the dose-dependent proliferation of human TF1 cells was found to be in the range of 2-10 ng/ml.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~22 kDa
20 µg/$291; 100 µg/$490; 1 mg/$1,891
CNTF Protein - Recombinant  Ciliary Neurotrophic Factor By SDS-PAGE
Select
E. coli
His-S
26.4 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
CNTF Protein - Recombinant  Ciliary Neurotrophic Factor By SDS-PAGE
Select
E. coli
His-T7
26.4kd
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CNTF Protein - 12.5% SDS-PAGE of human CNTF stained with Coomassie Blue
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Wheat Germ Extract
GST
49.3 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
22.8 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$273; 1 mg/$1,513
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
22.9 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$273; 1 mg/$1,740
CNTF Protein
Select
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
Viewing 1-21 of 21 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).