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The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
Gene Name: | cannabinoid receptor 2 (macrophage) |
Family/Subfamily: | GPCR , Cannabinoid |
Synonyms: | CNR2, Cannabinoid receptor 2, CB2, CB2 cannabinoid receptor, CX5, CB2R, HCB2, Cannabinoid CB2 receptor, CB-2, CB2 receptor |
Target Sequences: | NM_001841 NP_001832.1 P34972 |
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