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S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m7GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N7 methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.
Gene Name: | cap methyltransferase 2 |
Synonyms: | CMTR2, Adrift homolog, AFT, FTSJD1, MTr2, Protein adrift homolog |
Target Sequences: | NM_018348 NP_060818.4 Q8IYT2 |
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