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S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m7GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Gene Name: | cap methyltransferase 1 |
Synonyms: | CMTR1, FTSJD2, HMTr1, KIAA0082, MTr1, ISG95 |
Target Sequences: | D43949 BAA07893.2 Q8N1G2 |
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