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Sialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development and N-glycosylation is a common post-translational modification during cellular differentiation. Sialic acids play important roles in cell-cell communications and immune responses. Sialylated glycoprotein and glycolipid formation requires the activation of a sialic acid to a cytidine monophosphate (CMP) diester by the enzyme encoded by this gene: CMP-N-acetylneuraminic acid synthetase.
Gene Name: | cytidine monophosphate N-acetylneuraminic acid synthetase |
Synonyms: | CMAS, CMP-NeuNAc synthetase, CSS, CMP-Neu5Ac synthetase, CMP-NeuNAc synthase, CMP-sialic acid synthetase |
Target Sequences: | NM_018686 NP_061156.1 Q8NFW8 |
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