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CMA1 / Mast Cell Chymase

chymase 1, mast cell

CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.

Gene Name: chymase 1, mast cell
Family/Subfamily: Protease , Serine S1
Synonyms: CMA1, Chymase, Chymase, heart, Chymase, mast cell, CYH, Mast cell chymase, Mcpt5, MCT1, Mast cell protease 5, Mast cell protease I, Heart chymase, Alpha-chymase, Chymase 1, Chymase 1, mast cell, CYM
Target Sequences: NM_001836 NP_001827.1 P23946

Publications (1)

1
The muscular expression of RAS in patients with achalasia. Casselbrant A, Kostic S, Lönroth H. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2014 16:578-86. (WB; Human) [Full Text Article] [PubMed:24468662]

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Antibodies (57)
Primary (57)
CMA1 / Mast Cell Chymase (57)
Human (37)
Mouse (14)
Rat (9)
Dog (3)
Monkey (1)
IHC (20)
IHC-P (12)
WB (42)
ELISA (19)
ICC (1)
IP (3)
Peptide-ELISA (3)
rabbit (41)
mouse (14)
goat (1)
sheep (1)
Product Group
IHCPlus (1)
PathPlus Other (2)
IgG (20)
IgG1 (7)
IgG1,k (6)
IgG2a (1)
monoclonal mc (14)
polyclonal pc (43)
AA1 (1)
B7 (1)
CC1 (4)
APC (2)
APC Conjugated (3)
Azide-free (1)
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Concentrated (1)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
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PE Conjugated (3)
Preservative Free (4)
Unconjugated (27)
aa22-247 (9)
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aa1-247 (2)
aa20-247 (2)
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aa22-197 (1)
aa84-118 (1)
aa96-110 (1)
No (57)
CMA1 / Mast Cell Chymase Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal Antibody
Human
IHC-P, WB
Unconjugated
250 µl/$485
CMA1 / Mast Cell Chymase Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CMA1 / Mast Cell Chymase Goat anti-Human Polyclonal (aa96-110) Antibody
Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (aa20-247) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$896
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CMA1 / Mast Cell Chymase Sheep anti-Human Polyclonal (aa20-247) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$941
CMA1 / Mast Cell Chymase Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa164-213) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
CMA1 / Mast Cell Chymase Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa164-213) (Biotin) Antibody
Dog, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CMA1 / Mast Cell Chymase Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa164-213) (FITC) Antibody
Dog, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal Antibody
Human
IHC
Unconjugated
100 µg/$820
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (Biotin) (B7) Antibody
Human
ICC, IHC
Biotin Conjugated
100 µg/$947
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (APC) Antibody
Human
IHC
APC Conjugated
100 µl/$1,043
CMA1 / Mast Cell Chymase Antibody - Western blot of extracts of Mouse heart tissue, using CMA1 antibody.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CMA1 / Mast Cell Chymase Antibody - Immunohistochemistry - Anti-CMA1/Chymase Picoband Antibody
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa22-247) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (Azide-free) Antibody
Human
IHC, IHC-P, WB
Unconjugated, Azide-free
100 µl/$891
CMA1 / Mast Cell Chymase Antibody - 1:100 staining human lung carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CMA1 / Mast Cell Chymase Antibody - Western blot of recombinant CMA1 / MCT1 / Chymase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CMA1 / Mast Cell Chymase Rabbit anti-Mouse Polyclonal (aa9-247) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CMA1 / Mast Cell Chymase Antibody - Western Blot; Sample: Recombinant protein.
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CMA1 / Mast Cell Chymase Rabbit anti-Rat Polyclonal (aa22-197) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
CMA1 / Mast Cell Chymase Antibody - Western Blot; Sample: Recombinant protein.
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CMA1 / Mast Cell Chymase Rabbit anti-Rat Polyclonal (aa22-247) (HRP) Antibody
Rat
WB
HRP Conjugated
100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (Concentrated) (CC1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated, Concentrated
100 µg/$902
CMA1 / Mast Cell Chymase Antibody - Immunohistochemistry of paraffin-embedded human testicle using antibody at 1:100 dilution.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa1-247) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CMA1 / Mast Cell Chymase Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa1-247) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CMA1 / Mast Cell Chymase Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with Mast Cell Chymase antibody.
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CMA1 / Mast Cell Chymase Mouse anti-Human Monoclonal (CC1) Antibody
Human
IHC, WB
Unconjugated
0.1 ml/$282; 0.5 ml/$494; 1 ml/$725
CMA1 / Mast Cell Chymase Antibody - IHC-P: Chymase antibody testing of human placenta tissue
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CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal (aa22-247) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
Select
CMA1 / Mast Cell Chymase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
Select
CMA1 / Mast Cell Chymase Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
CMA1 / Mast Cell Chymase Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).