CLU / Clusterin

clusterin

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

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Products

ELISA Kits (48)

Type

Competitive EIA (4)

Custom (4)

Development Kit (6)

Sandwich (31)

Sandwich CLIA (3)

Target

CLU / Clusterin (48)

Reactivity

Human (13)

Mouse (10)

Rat (9)

Bovine (1)

Canine (1)

Chicken (1)

Dog (3)

Guinea pig (1)

Horse (1)

Monkey (1)

Pig (5)

Rabbit (1)

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Product Group

DevKit DuoPlus (6)

Format

12 x 8-Well Microstrips (6)

96-Well Microplate (10)

96-Well Strip Plate (25)

Antibody Pair and Standard (6)

Publications

No (47)

Yes (1)

Sample Type

Breast Milk (2)

Cell Culture Supernatants (18)

Cell Lysates (9)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (40)

Saliva (4)

Serum (41)

Tissue Homogenates (16)

Urine (7)

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F2753

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Saliva, Serum, Urine

Price:

1 Plate/$699

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F57

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

19.53 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F16326

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(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Monkey CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42428

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F689

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

63 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$534

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Mouse CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F2761

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

312 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$699

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Mouse CLU / Clusterin (Custom ELISA) ELISA Kit - LS-F377

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$610

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Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F3867

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

1.311 - 128 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$760

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Mouse CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F6174

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

18.75 - 1200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Breast Milk, Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine

Price:

1 Plate/$610

Select

Dog CLU / Clusterin (Competitive EIA) ELISA Kit - LS-F10145

Type:

Competitive EIA

Format:

96-Well Microplate

Reactivity:

Dog

Range:

7.813 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$744

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Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F4992

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$750

Select

Mouse CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F10199

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$744

Select

Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F11142

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F13119

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Mouse CLU / Clusterin (Custom ELISA) ELISA Kit - LS-F16325

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Dog CLU / Clusterin (Custom ELISA) ELISA Kit - LS-F16327

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Bovine CLU / Clusterin (Custom ELISA) ELISA Kit - LS-F16328

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human CLU / Clusterin (CLIA) ELISA Kit - LS-F29092

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat CLU / Clusterin (CLIA) ELISA Kit - LS-F31183

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse CLU / Clusterin (CLIA) ELISA Kit - LS-F30590

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

0.625 - 40 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F34551

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F34550

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F34552

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F39703

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

312 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Guinea pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42427

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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