CLU / Clusterin

clusterin

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

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Products

ELISA Kits (48)

Type

Competitive EIA (4)

Custom (4)

Development Kit (6)

Sandwich (31)

Sandwich CLIA (3)

Target

CLU / Clusterin (48)

Reactivity

Human (13)

Mouse (10)

Rat (9)

Bovine (1)

Canine (1)

Chicken (1)

Dog (3)

Guinea pig (1)

Horse (1)

Monkey (1)

Pig (5)

Rabbit (1)

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Product Group

DevKit DuoPlus (6)

Format

12 x 8-Well Microstrips (6)

96-Well Microplate (10)

96-Well Strip Plate (25)

Antibody Pair and Standard (6)

Publications

No (47)

Yes (1)

Sample Type

Breast Milk (2)

Cell Culture Supernatants (18)

Cell Lysates (9)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (40)

Saliva (4)

Serum (41)

Tissue Homogenates (16)

Urine (7)

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Monkey CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42428

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F16326

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F57

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

19.53 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F2753

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Saliva, Serum, Urine

Price:

1 Plate/$699

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F689

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

63 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$534

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Mouse CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F2761

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

312 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$699

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Dog CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F54892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Dog

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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DevKit DuoPlus Pig CLU / Clusterin ELISA Development Kit - LS-F71826

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Pig

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,250; 1000 Wells/$1,859

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DevKit DuoPlus Rat CLU / Clusterin ELISA Development Kit - LS-F72127

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

500 Wells/$1,305; 1000 Wells/$1,952

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DevKit DuoPlus Canine CLU / Clusterin ELISA Development Kit - LS-F72086

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Canine

Range:

6.24 - 400 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,296; 1000 Wells/$1,937

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DevKit DuoPlus Bovine CLU / Clusterin ELISA Development Kit - LS-F72223

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Bovine

Range:

31.2 - 2000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,352; 1000 Wells/$2,030

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DevKit DuoPlus Mouse CLU / Clusterin ELISA Development Kit - LS-F71391

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

37.5 - 2400 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Breast Milk, Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine

Price:

500 Wells/$1,005; 1000 Wells/$1,451

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DevKit DuoPlus Human CLU / Clusterin ELISA Development Kit - LS-F71366

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

25 - 1600 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Saliva, Serum, Tissue Homogenates, Urine

Price:

500 Wells/$1,005; 1000 Wells/$1,451

Select

Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F39703

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

312 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

Select

Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F57248

Type:

Sandwich

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Saliva, Serum, Urine

Price:

1 Plate/$699

Select

Guinea pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42427

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42429

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

15.625 - 1000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Chicken CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F42426

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

15.625 - 1000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F55391

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$816

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Horse CLU / Clusterin (Competitive EIA) ELISA Kit - LS-F54137

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Horse

Range:

15.6 - 1000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$822

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Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F67112

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$476

Select

Pig CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F21881

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Pig

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Rat CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F20781

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F21758

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

2.5 - 160 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human CLU / Clusterin (Sandwich ELISA) ELISA Kit - LS-F21784

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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