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CLU / Clusterin
clusterin
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
| Gene Name: | clusterin |
| Synonyms: | CLU, APO-J, Apolipoprotein J, CLU1, Clusterin, Complement lysis inhibitor, CLI, AAG4, Aging-associated protein 4, Ku70-binding protein 1, KUB1, SGP2, APOJ, SGP-2, Sulfated glycoprotein 2, CLU2, Complement cytolysis inhibitor, NA1/NA2, SP-40 |
| Target Sequences: | NM_001831 NP_001822.3 P10909 |
Publications (4)
1
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Journal of neuropathology and experimental neurology. 2015 74:672-87. (WB; Human)
[Full Text Article]
[PubMed:26083568]
[PMC:PMC4471879]
Related Antibodies: LS-C44980.
2
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury. Das Gupta S, Lipponen A, Paldanius KMA, Puhakka N, Pitkänen A. Science advances. 2019 December;9:20208. [Full Text Article]
[PubMed:31882899]
[PMC:PMC6934775]
3
Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease. Denise Traxler, Andreas Spannbauer, Patrick Einzinger, Julia Mester-Tonczar, Dominika Lukovic, Johannes Winkler, Katrin Zlabinger, Alfred Gugerell, LJubica Mandic, Mariann Gyöngyösi, Noemi Pavo. International journal of molecular sciences. 2020 June;21: [Full Text Article]
[PubMed:32605184]
[PMC:PMC7369988]
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(194)
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CLU / Clusterin
(194)
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Publications
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(193)
Yes
(1)
CLU / Clusterin Goat anti-Human Polyclonal (aa488-501) Antibody
Human, Monkey
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CLU / Clusterin Mouse anti-Human Monoclonal (3R3/2) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$533
CLU / Clusterin Goat anti-Mouse Polyclonal (aa435-448) Antibody
Mouse, Rat
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
CLU / Clusterin Mouse anti-Human Monoclonal (aa75-501) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
250 µg/$1,068
CLU / Clusterin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
500 µg/$634
CLU / Clusterin Mouse anti-Human Monoclonal (Hs-3) Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CLU / Clusterin Rabbit anti-Human Polyclonal (Glu436) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CLU / Clusterin Mouse anti-Human Monoclonal (aa1-333) (1A11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CLU / Clusterin Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
100 µl/$1,144
CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
CLU / Clusterin Mouse anti-Human Monoclonal (1A11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
100 µg/$638
CLU / Clusterin Rabbit anti-Human Polyclonal (370-450 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CLU / Clusterin Mouse anti-Human Monoclonal (CLI-9) Antibody
Human
ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$490
CLU / Clusterin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
500 µg/$994
CLU / Clusterin Mouse anti-Human Monoclonal (aa23-227) (OTI5D3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
CLU / Clusterin Rabbit anti-Human Polyclonal (aa71-99) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$485
CLU / Clusterin Rabbit anti-Human Polyclonal (aa71-99) (APC) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
APC Conjugated
200 µl/$952
CLU / Clusterin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$323
CLU / Clusterin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
CLU / Clusterin Mouse anti-Human Monoclonal (aa75-501) Antibody
Human
ELISA
Unconjugated
100 µg/$930; 500 µg/$1,795
CLU / Clusterin Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF, WB
Unconjugated
100 µl/$412
CLU / Clusterin Rabbit anti-Mouse Monoclonal (Preservative Free) (102) Antibody
Mouse
ELISA
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
CLU / Clusterin Goat anti-Human Polyclonal (aa44-58) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
CLU / Clusterin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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