CLNS1A

chloride channel, nucleotide-sensitive, 1A

Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

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Products

Antibodies (16)

Type

Primary (16)

Target

CLNS1A (16)

Reactivity

Human (15)

Mouse (7)

Rat (5)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (4)

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Application

IHC (4)

IHC-P (2)

WB (16)

Flo (3)

DB (1)

ELISA (3)

ICC (1)

IF (2)

IP (2)

Peptide-ELISA (2)

Host

rabbit (14)

mouse (2)

Isotype

IgG (7)

IgG1 (2)

Clonality

monoclonal mc (2)

polyclonal pc (14)

Clone

2187C2a (1)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (13)

Epitope

aa138-187 (4)

160-240 aa, C-terminal (1)

C-Terminus (1)

aa148-176 (1)

aa184-233 (1)

aa187-237 (1)

aa189-216 (1)

Publications

No (16)

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CLNS1A Antibody (aa148-176) LS-C99241

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (aa148-176) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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CLNS1A Antibody (clone 2187C2a) LS-C342535

Antibody:

CLNS1A Mouse anti-Human Monoclonal (2187C2a) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

DB, ICC, IF, WB

Format:

Unconjugated

Price:

100 µg/$486

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CLNS1A Antibody (aa189-216) LS-C99240

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (aa189-216) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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CLNS1A Antibody LS-C411273

Antibody:

CLNS1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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CLNS1A Antibody (aa187-237) LS-C762040

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (aa187-237) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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CLNS1A Antibody LS-C805151

Antibody:

CLNS1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CLNS1A Antibody LS-C666295

Antibody:

CLNS1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

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CLNS1A Antibody (160-240 aa, C-terminal) LS-C385484

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (160-240 aa, C-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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CLNS1A Antibody LS-C824242

Antibody:

CLNS1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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CLNS1A Antibody (aa184-233) LS-C291341

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (aa184-233) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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CLNS1A Antibody (C-Terminus) LS-C352016

Antibody:

CLNS1A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rabbit, Dog, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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CLNS1A Antibody LS-C79406

Antibody:

CLNS1A Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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CLNS1A Antibody (aa138-187) LS-C135258

Antibody:

CLNS1A Rabbit anti-Mouse Polyclonal (aa138-187) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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CLNS1A Antibody (aa138-187, HRP) LS-C455273

Antibody:

CLNS1A Rabbit anti-Mouse Polyclonal (aa138-187) (HRP) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

CLNS1A Antibody (aa138-187, Biotin) LS-C455271

Antibody:

CLNS1A Rabbit anti-Mouse Polyclonal (aa138-187) (Biotin) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

CLNS1A Antibody (aa138-187, FITC) LS-C455272

Antibody:

CLNS1A Rabbit anti-Mouse Polyclonal (aa138-187) (FITC) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

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