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Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene Name: | CDC-like kinase 3 |
Family/Subfamily: | Protein Kinase , LAMMER/Clk |
Synonyms: | CLK3, PHCLK3/152, CDC-like kinase 3, Hclk3, PHCLK3 |
Target Sequences: | NM_003992 NP_003983.2 P49761 |
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