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Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Gene Name: | chloride intracellular channel 4 |
Family/Subfamily: | Ion Channel , Chloride channel - intracellular |
Synonyms: | CLIC4, CLIC4L, DKFZP566G223, Mc3s5, HuH1, MTCLIC, p64H1 |
Target Sequences: | NM_013943 NP_039234.1 Q9Y696 |
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