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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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CLEC4E / MINCLE
C-type lectin domain family 4, member E
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
| Gene Name: | C-type lectin domain family 4, member E |
| Synonyms: | CLEC4E, CLECSF9, MINCLE |
| Target Sequences: | NM_014358 NP_055173.1 Q9ULY5 |
![CLEC4E / MINCLE Antibody - Western Blot: CLEC4E Antibody - analysis of CLEC4E using CLEC4E antibody. Human spleen cell lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse spleen, 4) rat spleen, 5) Ramos and 6) THP1 cell lysate probed with 2 ug/ml of CLEC4E antibody. [Character a1]s goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.](https://lsbio-7d62.kxcdn.com/image2/clec4e-mincle-antibody-ls-c359402/257477_5125332.jpg)
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