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CLEC12A / CD371

C-type Lectin Domain Family 12, Member A

CLEC12A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.

Gene Name: C-type Lectin Domain Family 12, Member A
Synonyms: CLEC12A, C-type lectin-like molecule 1, C-type lectin protein CLL-1, DCAL-2, DCAL2, CLL1, MICL, C-type lectin superfamily, C-type lectin-like molecule-1, CLL-1, CD371
Target Sequences: NM_138337 NP_612210.4 Q5QGZ9

Publications (1)

1
Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease. Sebastian Werneburg, Jonathan Jung, Rejani B Kunjamma, Seung-Kwon Ha, Nicholas J Luciano, Cory M Willis, Guangping Gao, Natalia P Biscola, Leif A Havton, Stephen J Crocker, Brian Popko, Daniel S Reich, Dorothy P Schafer. Immunity. 2020 January;52:167-182.e7. [Full Text Article] [PubMed:31883839] [PMC:PMC6996144] Related Antibodies: LS-C377776.

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Products
Proteins (10)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Recombinant (5)
CLEC12A / CD371 (10)
SDS-PAGE (1)
No (10)
10His, N-terminus + Myc, C-terminus (1)
6His, N-terminus (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His,N-terminus (1)
Myc-DDK (Flag) (4)
Human (7)
Mouse (1)
293T Cells (2)
Baculovirus (1)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
CLEC12A / CD371 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
~37-50 kDa
10 µg/$289; 50 µg/$360
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HEK 293 Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26 kDa
100 µg/$1,189; 1 mg/$5,985
CLEC12A / CD371 Protein
Select
HEK 293 Cells
His,N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human CLEC12A consists of 221 amino acids and has a calculated molecular mass of 26 kDa. The apparent molecular mass of rhCLEC12A is approximately 40-45 kDa in SDS-PAGE under reducing conditions.
100 µg/$519; 1 mg/$2,551
CLEC12A / CD371 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CLEC12A / CD371 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
CLEC12A / CD371 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.1 kDa
20 µg/$150
Select
HEK 293 Cells
6His, N-terminus
24 kDa
200 µl/$283
CLEC12A / CD371 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.1 kDa
100 µg/$494
CLEC12A / CD371 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
CLEC12A / CD371 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Baculovirus
10His, N-terminus + Myc, C-terminus
27.8 kDa
100 µg/$1,164; 20 µg/$475; 1 mg/$2,187
Viewing 1-10 of 10 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).