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CLDN18 / Claudin 18

claudin 18

CLDN18 / Claudin 18 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: claudin 18
Family/Subfamily: Claudin , not assigned-Claudin
Synonyms: CLDN18, Claudin 18, Claudin-18, SFTPJ, SFTA5, Surfactant associated 5
Target Sequences: NM_016369 NP_057453.1 P56856

Publications (1)

1
Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. Norika Chiba, Kenichi Shimada, Shuang Chen, Heather D Jones, Randa Alsabeh, Anatoly V Slepenkin, Ellena Peterson, Timothy R Crother, Moshe Arditi. Journal of immunology (Baltimore, Md. : 1950). 2015 April;194:3840-51. [Full Text Article] [PubMed:25754739] [PMC:PMC4390505] Related Antibodies: LS-C816125.

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ELISA Kits (10)
Sandwich (9)
Sandwich CLIA (1)
CLDN18 / Claudin 18 (10)
Human (3)
Rat (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (8)
No (10)
Cell Lysates (1)
Plasma (2)
Serum (2)
Tissue Homogenates (2)
CLDN18 / Claudin 18 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CLDN18 / Claudin 18 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CLDN18 / Claudin 18 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$750
CLDN18 / Claudin 18 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CLDN18 / Claudin 18 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CLDN18 / Claudin 18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CLDN18 / Claudin 18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CLDN18 / Claudin 18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CLDN18 / Claudin 18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
CLDN18 / Claudin 18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).