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The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
Gene Name: | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
Synonyms: | CITED4, MRG2, Transcriptional co-activator 4, MRG-2, MSG1-related protein 2 |
Target Sequences: | NM_133467 NP_597724.1 Q96RK1 |
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