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CIRP / CIRBP

cold inducible RNA binding protein

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor By similarity. Promotes assembly of stress granules (SGs), when overexpressed.

Gene Name: cold inducible RNA binding protein
Synonyms: CIRBP, A18 hnRNP, A18HNRNP, CIRP
Target Sequences: NM_001280 NP_001271.1 Q14011

Publications (3)

1
Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis. William Royster, Hui Jin, Ping Wang , Monowar Aziz. Molecular medicine (Cambridge, Mass.). 2021 May;27:55. [Full Text Article] [PubMed:34058975] [PMC:PMC8165807]
2
Extracellular CIRP activates STING to exacerbate hemorrhagic shock. Kehong Chen, Joaquin Cagliani, Monowar Aziz, Chuyi Tan, Max Brenner, Ping Wang. JCI insight. 2021 July;6:e143715. [Full Text Article] [PubMed:34291735] [PMC:PMC8410031]
3
Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation. Steven D Gurien, Monowar Aziz, Hui Jin, Haichao Wang, Mingzhu He, Yousef Al-Abed, Jeffrey M Nicastro, Gene F Coppa, Ping Wang. EMBO reports. 2020 Janurary;21:e48075. [Full Text Article] [PubMed:31724825]

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ELISA Kits (6)
Custom (1)
Sandwich (5)
CIRP / CIRBP (6)
Human (3)
Mouse (1)
Rat (2)
96-Well Strip Plate (6)
No (4)
Yes (2)
Cell Culture Supernatants (1)
Cell Lysates (2)
Plasma (3)
Serum (3)
Tissue Homogenates (4)
CIRP / CIRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CIRP / CIRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
CIRP / CIRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
CIRP / CIRBP ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
CIRP / CIRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CIRP / CIRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.12 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).