CIB1 / KIP

calcium and integrin binding 1 (calmyrin)

Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CIB1 / KIP (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CIB1 / KIP Protein (Recombinant His) - LS-G3369

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human CIB1 / KIP Protein (Recombinant GST) (Full Length) - LS-G32194

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.75 kDa

Price:

10 µg/$479; 25 µg/$670

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CIB1 / KIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100802

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

100 µg/$494

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Human CIB1 / KIP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66989

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

20 µg/$1,107

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Human CIB1 / KIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78867

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.5 kDa

Price:

20 µg/$150

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Human CIB1 / KIP Protein (Recombinant His-T7) (aa2-191) - LS-G24820

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.0 kDa

Price:

10 µg/$266; 50 µg/$349; 100 µg/$555; 200 µg/$692; 1 mg/$1,709; 500 µg/$1,286; 5 mg/$2,659; 2 mg/$1,886

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