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Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Gene Name: | cysteine and histidine-rich domain (CHORD) containing 1 |
Synonyms: | CHORDC1, CHORD-containing protein 1, CHP-1, Protein morgana |
Target Sequences: | NM_012124 NP_036256.2 Q9UHD1 |
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