CHMP6

charged multivesicular body protein 6

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CHMP6 (4)

Publications

No (4)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CHMP6 Protein (Recombinant His) - LS-G1729

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human CHMP6 Protein (Recombinant GST) (Full Length) - LS-G35225

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CHMP6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91781

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$150

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CHMP6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109897

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

100 µg/$494

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