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Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Gene Name: | choroideremia (Rab escort protein 1) |
Synonyms: | CHM, Choroideraemia protein, DXS540, GGTA, HSD-32, REP-1, REP1, Rab escort protein 1, TCD, TCD protein |
Target Sequences: | NM_000390 NP_000381.1 P24386 |
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