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CHL1

cell adhesion molecule L1-like

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.

Gene Name: cell adhesion molecule L1-like
Synonyms: CHL1, CALL, Cell adhesion molecule L1-Like, L1 cell adhesion molecule 2, L1CAM2, Neural cell adhesion molecule, Close homolog of L1
Target Sequences: NM_006614 NP_006605.2 O00533

Publications (1)

1
Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Sabrina Simoes, Jessica L Neufeld, Gallen Triana-Baltzer, Setareh Moughadam, Emily I Chen, Milankumar Kothiya, Yasir H Qureshi, Vivek Patel, Lawrence S Honig, Hartmuth Kolb, Scott A Small. Science translational medicine. 2020 November;12: [Full Text Article] [PubMed:33239387] [PMC:PMC7901670] Related Antibodies: LS-C485419.

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Proteins (5)
Recombinant (5)
CHL1 (5)
No (5)
Fc (1)
GST, N-terminus (1)
His (1)
His,C-terminus (1)
Human (2)
Mouse (3)
HEK 293 Cells (1)
Human Cells (3)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (4)
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
139.4 kDa
50 µg/$721
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Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
113.3 kDa
50 µg/$721
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
120 kDa
50 µg/$721
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HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
113.9 kDa
50 µg/$721
CHL1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).