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DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression.
Gene Name: | chromodomain helicase DNA binding protein 2 |
Synonyms: | CHD2, ATP-dependent helicase CHD2, CHD-2 |
Target Sequences: | NM_001271 NP_001262.3 O14647 |
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