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Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.
Gene Name: | Centrosomal Protein 63kDa |
Synonyms: | CEP63, Centrosomal protein of 63 kDa, Centrosome protein CEP63, Centrosomal protein 63kDa |
Target Sequences: | NM_025180 NP_079456.2 Q96MT8 |
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