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CENPM

centromere protein M

CENPM is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants.

Gene Name: centromere protein M
Synonyms: CENPM, C22orf18, Centromere protein M, BK250D10.2, CENP-M, ICEN39, PANE1
Target Sequences: NM_024053 NP_076958.1 Q9NSP4

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
CENPM (6)
No (6)
GST (1)
Myc-DDK (Flag) (5)
Human (4)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
CENPM Protein - Purified recombinant protein CENPM was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
19.6 kDa
20 µg/$1,107
CENPM Protein - 12.5% SDS-PAGE of human C22orf18 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.54 kDa
10 µg/$479; 25 µg/$670
CENPM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
6.1 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
19.6 kDa
20 µg/$150
CENPM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
19.6 kDa
100 µg/$494
CENPM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
6.1 kDa
100 µg/$494
Viewing 1-6 of 6 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).