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CENPF / CENP-F
centromere protein F, 350/400kDa
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
| Gene Name: | centromere protein F, 350/400kDa |
| Synonyms: | CENPF, AH antigen, Centromere protein F, CENF, CENP-F, Kinetochore protein CENPF, Mitosin, CENP-F kinetochore protein, Hcp-1, PRO1779 |
| Target Sequences: | NM_016343 NP_057427.3 P49454 |
Publications (16)
1
Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J. Molecular and cellular biology. 2000 20:7613-23.
[PubMed:11003657]
[PMC:PMC86321]
2
Sgt1 is required for human kinetochore assembly. Steensgaard P, Garr M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A. EMBO reports. 2004 5:626-31.
[PubMed:15133482]
[PMC:PMC1299074]
3
Human Cdc45 is a proliferation-associated antigen. Pollok S, Bauerschmidt C, Snger J, Nasheuer HP, Grosse F. The FEBS journal. 2007 274:3669-84.
[PubMed:17608804]
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(24)
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(24)
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CENPF / CENP-F
(24)
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(24)
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(11)
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(5)
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(14)
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(6)
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(6)
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(2)
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(19)
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(4)
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(10)
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(1)
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(2)
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(1)
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monoclonal mc
(4)
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(20)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(17)
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aa436-637
(8)
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(3)
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(2)
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aa3150-3200
(1)
aa3198-3210
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Publications
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(21)
Yes
(3)
CENPF / CENP-F Mouse anti-Human Monoclonal (aa1759-2093) (14C10 1D8) Antibody
Human
IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$440
CENPF / CENP-F Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 mg/$460
CENPF / CENP-F Mouse anti-Human Monoclonal (aa1759-2093) Antibody
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$515
CENPF / CENP-F Goat anti-Human Polyclonal (aa3198-3210) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
CENPF / CENP-F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$331
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa2350-2400) Antibody
Human
IF, IHC
Unconjugated
1 µg/$295; 100 µl/$532
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa1800-1850) Antibody
Human
ICC, IF, IP
Unconjugated
10 µg/$295; 100 µl/$514
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa1800-1850) Antibody
Human
ICC, IF
Unconjugated
2.5 µg/$295; 100 µl/$532
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa2350-2400) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
CENPF / CENP-F Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CENPF / CENP-F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CENPF / CENP-F Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CENPF / CENP-F Mouse anti-Human Monoclonal (aa1759-2093) (Preservative Free) (7F11.2) Antibody
Human
IHC
Unconjugated, Preservative Free
100 µl/$450
CENPF / CENP-F Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$786
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa436-637) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
CENPF / CENP-F Rabbit anti-Human Polyclonal (aa3150-3200) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
CENPF / CENP-F Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µg/$357
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